The project is to be carried out in the Loschmidt Laboratories, which are part of the Research Centre for Toxic Compounds in the Environment (RECETOX), in the Faculty of Science at the Masaryk University (MU, Brno, CZ). MU is the second largest university in the Czech Republic, a member of the Compostela Group and the Utrecht Network. Research projects in Loschmidt Laboratories are dedicated to fundamental principles of enzymatic catalysis, and bioengineering of new enzymes for environmental and biomedical applications. The long-term screening for novel enzymes and their properties has resulted in: (i) >50 protein structures solved by X-ray crystallography, (ii) >200 scientific publications, (iii) 6 patents and (vi) 10 software tools for protein engineering available at


Dr. Jiří Damborský

Dr. David Bednar




Zerotinovo namesti 9

60177 Brno Stred

Czech Republic


Short Name



Work Packages

Role in Sinfonia

Development of bioinformatic tools, in silico design of optimized modules encoding biofluorination, PFHA biosynthesis and DNA and metabolite repair activities

Key people involved and expertise

Prof. Jiří Damborský (male). Senior Scientist and group leader; expert in bioinformatic-based design of enzymes and metabolic pathways in different systems, successful proven track-record in establishing spin-offs/startups.

Dr. David Bednar (male). Junior team leader; expert in molecular modelling, bioinformatics and computational protein design; engineering or stable and soluble enzymes; teaching of structural biology